High plasma concentrations of cortisol and thromboxane B2 in patients with depression.

@article{Piccirillo1994HighPC,
  title={High plasma concentrations of cortisol and thromboxane B2 in patients with depression.},
  author={Gianfranco Piccirillo and Filippo Luca Fimognari and V Infantino and Girolamo Monteleone and G B Fimognari and D Falletti and Vincenzo Marigliano},
  journal={The American journal of the medical sciences},
  year={1994},
  volume={307 3},
  pages={228-32}
}
Modulation of the hypothalamic-pituitary-adrenal axis in major depression is thought to depend on the hypothalamus and other areas of the central nervous system, or both. Hypothalamic over-activity may be responsible for the hypercortisolism observed in 50% of depressed subjects. To investigate the relation between psychosocial factors and cardiovascular disease, morning (8 AM) plasma concentrations of cortisol and thromboxane B2 (the stable metabolite of thromboxane A2, an eicosanoid closely… CONTINUE READING