High physiological levels of melatonin in the bile of mammals.

  title={High physiological levels of melatonin in the bile of mammals.},
  author={Dunxian Tan and L. Manchester and Russell J Reiter and Wen-bo Qi and Martha A. Hanes and Nancy Farley},
  journal={Life sciences},
  volume={65 23},
Bile is an important physiological bodily fluid which functions in the regulation of cholesterol metabolism, promotes the absorption of lipid and fat-soluble vitamins by the gut and serves in the excretion of toxic substances from the liver. Conversely, due to autooxidative processes bile is highly toxic to the hepatocyte and gastrointestinal epithelium. In this investigation, extremely high day time physiological levels of the endogenous antioxidant, melatonin, were measured in the bile of… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 79 extracted citations

Melatonin Plays a Protective Role in Postburn Rodent Gut Pathophysiology

International journal of biological sciences • 2010
View 9 Excerpts
Highly Influenced

REVIEW: Gastrointestinal Melatonin: Localization, Function, and Clinical Relevance

Digestive Diseases and Sciences • 2004
View 4 Excerpts
Highly Influenced

Melatonin Mitigates Mitochondrial Meltdown: Interactions with SIRT3

International journal of molecular sciences • 2018
View 2 Excerpts

Similar Papers

Loading similar papers…