High persistence rate of hepatitis B virus in a hydrodynamic injection-based transfection model in C3H/HeN mice.

Abstract

AIM To optimize the viral persistence rate in a hydrodynamic injection (HI) based hepatitis B virus (HBV) transfection mouse model. METHODS (1) 5-6-wk-old male C3H/HeN and C57BL/6 mice were hydrodynamically injected with 10 μg endotoxin-free pAAV/HBV1.2 plasmid DNA via the tail vein. Hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg) and… (More)
DOI: 10.3748/wjg.v21.i12.3527

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