High-performance size-exclusion chromatographic analysis of dextran-methylprednisolone hemisuccinate in rat plasma.

  • Reza Mehvar
  • Published 2000 in
    Journal of chromatography. B, Biomedical sciences…


A size exclusion chromatographic method is presented for the measurement of the concentrations of a macromolecular prodrug of methylprednisolone (MP), dextran-methylprednisolone succinate (DEX-MPS), in rat plasma. After precipitation of the plasma (100 microl) proteins with perchloric acid, the samples are injected into a size exclusion column with a mobile… (More)


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