High performance screening, structural and molecular dynamics analysis to identify H1 inhibitors from TCM Database@Taiwan.

@article{Chang2011HighPS,
  title={High performance screening, structural and molecular dynamics analysis to identify H1 inhibitors from TCM Database@Taiwan.},
  author={Su-Sen Chang and Hung-Jin Huang and Calvin Yu-Chian Chen},
  journal={Molecular bioSystems},
  year={2011},
  volume={7 12},
  pages={3366-74}
}
New-type oseltamivir-resistant H1N1 influenza viruses have been a major threat to human health since the 2009 flu pandemic. To resolve the drug resistance issue, we aimed to identify a new type of inhibitors against H1 from traditional Chinese medicine (TCM) by employing the world's largest TCM database () for virtual screening and molecular dynamics (MD). From the virtual screening results, sodium (+)-isolaricireinol-2 alpha-sulfate, sodium 3,4-dihydroxy-5-methoxybenzoic acid methyl ester-4… CONTINUE READING
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