High-performance liquid chromatography method for determining alendronate sodium in human plasma by detecting fluorescence: application to a pharmacokinetic study in humans.

Abstract

A high-performance liquid chromatographic (HPLC) method was developed using diethylamine (DEA) solid-phase extraction (SPE), 9-fluorenylmethyl derivative (FMOC) and fluorescence detection for quantifying alendronate in human plasma. Sample preparation involved a manual protein precipitation with trichloroacetic acid, a manual coprecipitation of the… (More)

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Cite this paper

@article{Yun2006HighperformanceLC, title={High-performance liquid chromatography method for determining alendronate sodium in human plasma by detecting fluorescence: application to a pharmacokinetic study in humans.}, author={Min-hyuk Yun and Kwang-il Kwon}, journal={Journal of pharmaceutical and biomedical analysis}, year={2006}, volume={40 1}, pages={168-72} }