High performance liquid chromatography method for the pharmacokinetic study of bicalutamide SMEDDS and suspension formulations after oral administration to rats.

@article{Singh2009HighPL,
  title={High performance liquid chromatography method for the pharmacokinetic study of bicalutamide SMEDDS and suspension formulations after oral administration to rats.},
  author={Ajeet Kumar Singh and Akash Chaurasiya and Gaurav Kumar Jain and Anshumali Awasthi and Dinesh Prasad Asati and Gautam Mishra and Roop Krishen Khar and Rama Mukherjee},
  journal={Talanta},
  year={2009},
  volume={78 4-5},
  pages={1310-4}
}
Bicalutamide is a non-steroidal antiandrogen and is an oral medication that is used for treating prostate cancer. To evaluate the bioavailability of bicalutamide from bicalutamide self-microemulsifying drug delivery systems (SMEDDS) and bicalutamide suspension formulations, a sensitive, specific reversed-phase high performance liquid chromatographic (HPLC) method using ultraviolet detection was developed and validated for the analysis of bicalutamide (BCT) in rat blood plasma. Letrozole (LZ… CONTINUE READING