High performance liquid chromatography-mass spectrometry assay for polymyxin B1 and B2 in human plasma.

Abstract

BACKGROUND Polymyxin B is an old antibiotic with increasing clinical relevance in the treatment of multidrug-resistant Gram-negative bacterial infections. However, current dosing regimens are largely empiric as clinical pharmacological characterization of the drug has been hindered by the lack of assays to measure polymyxin B in human plasma. METHODS A… (More)
DOI: 10.1097/FTD.0b013e31825c827a

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@article{Thomas2012HighPL, title={High performance liquid chromatography-mass spectrometry assay for polymyxin B1 and B2 in human plasma.}, author={Tiffany A Thomas and Emily C Broun and Kirsten M. Abildskov and Christine J. Kubin and Jennifer Horan and Michael T. Yin and Serge C. L. M. Cremers}, journal={Therapeutic drug monitoring}, year={2012}, volume={34 4}, pages={398-405} }