High-performance liquid chromatographic determination of the stability of sisomicin in hydrophilic petrolatum ointment.

@article{Yamamura1983HighperformanceLC,
  title={High-performance liquid chromatographic determination of the stability of sisomicin in hydrophilic petrolatum ointment.},
  author={Keiko Yamamura and Makoto Nakao and J Yamada and Toshihisa Yotsuyanagi},
  journal={Chemical \& pharmaceutical bulletin},
  year={1983},
  volume={31 10},
  pages={
          3632-6
        }
}
For the purpose of investigating of its suitability for topical application, the stability of sisomicin incorporated in hydrophilic petrolatum was investigated under various storage conditions by high-performance liquid chromatography. Sisomicin was extracted from the oleaginous vehicle, which was kept in a liquid state by adding liquid paraffin, using pH 6.5 phosphate buffer. An appropriate retention behavior of the antibiotic is obtained on a μBondapak-C18 column with a mobile phase of 2.0… Expand
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