High performance liquid chromatographic determination of mazindol in human plasma.

@article{Kaddoumi2001HighPL,
  title={High performance liquid chromatographic determination of mazindol in human plasma.},
  author={Amal Kaddoumi and Masanobu Mori and K Nanashima and Michio Kono and Kenichiro Nakashima},
  journal={The Analyst},
  year={2001},
  volume={126 11},
  pages={1963-8}
}
A simple and convenient high performance liquid chromatographic method with UV detection is described for the determination of mazindol [5-(p-chlorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol] and its major metabolite, 2-(2-aminoethyl)-3-(p-chlorophenyl)-3-hydroxyphthalimidine (Met), in human plasma. The analytes were extracted with ethyl acetate from plasma samples and separated on a C18 column using acetonitrile-0.067 mol dm(-3) phosphate buffer (pH 3.5) (24 + 76 v/v) as a mobile phase… CONTINUE READING