High-performance liquid chromatographic determination of doxazosin in human plasma for bioequivalence study of controlled release doxazosin tablets.

@article{Kim2006HighperformanceLC,
  title={High-performance liquid chromatographic determination of doxazosin in human plasma for bioequivalence study of controlled release doxazosin tablets.},
  author={Young Jae Kim and Yoonjin Lee and Myung Kang and Jin Seo Huh and Mikyeong Yoon and Jaehwi Lee and Young Wook Choi},
  journal={Biomedical chromatography : BMC},
  year={2006},
  volume={20 11},
  pages={1172-7}
}
A highly sensitive high-performance liquid chromatographic quantification method with fluorescence detection was developed and validated for the determination of doxazosin in human plasma. The developed method employed one-step extraction of doxazosin from plasma matrix with ethyl acetate using propranolol as an internal standard. Chromatographic separation was obtained within 8.0 min using a reverse-phase Capcell-Pak C(18) column (150 x 4.6 mm i.d., 5 microm) and the mobile phase consisted of… CONTINUE READING