High-performance liquid chromatographic determination of aspirin and its metabolites in plasma and urine.

@article{Bakar1983HighperformanceLC,
  title={High-performance liquid chromatographic determination of aspirin and its metabolites in plasma and urine.},
  author={S K Bakar and S B Niazi},
  journal={Journal of pharmaceutical sciences},
  year={1983},
  volume={72 9},
  pages={1020-3}
}
A simple quantitative method for the rapid determination of aspirin and its metabolites, salicylic acid, salicyluric acid, and gentisic acid, in plasma and urine using o-toluic and o-anisic acids, respectively, as internal standards was developed. Plasma proteins were precipitated by the addition of acetonitrile and, after centrifugation, the supernatant fluid was injected directly onto a reverse-phase column. The mobile phase consisted of an isocratic mixture of water, methanol, and glacial… CONTINUE READING

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