High-performance liquid-chromatographic determination of 5-aminosalicylic acid and its metabolites in blood plasma.

@article{Nobilis2006HighperformanceLD,
  title={High-performance liquid-chromatographic determination of 5-aminosalicylic acid and its metabolites in blood plasma.},
  author={Milan Nobilis and Zuzana Vyb{\'i}ralov{\'a} and Květa Sl{\'a}dkov{\'a} and Miroslav L{\'i}sa and Michal Hol{\vc}apek and Jaroslav Kvetina},
  journal={Journal of chromatography. A},
  year={2006},
  volume={1119 1-2},
  pages={299-308}
}
Mesalazine (5-aminosalicylic acid, 5-ASA), an anti-inflammatory agent for the treatment of inflammatory bowel diseases, is metabolized in organism to the principal biotransformation product, N-acetyl-5-ASA. Some other phase II metabolites (N-formyl-5-ASA, N-butyryl-5-ASA, N-beta-d-glucopyranosyl-5-ASA) have also been described. 5-ASA is a polar compound and besides it exhibits amphoteric properties. The extraction of this compound from biomatrices and its chromatographic analysis is complicated… CONTINUE READING
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