High-performance liquid chromatographic method with UV photodiode-array, fluorescence and mass spectrometric detection for simultaneous determination of galantamine and its phase I metabolites in biological samples.

@article{Malkov2007HighperformanceLC,
  title={High-performance liquid chromatographic method with UV photodiode-array, fluorescence and mass spectrometric detection for simultaneous determination of galantamine and its phase I metabolites in biological samples.},
  author={Jana Mal{\'a}kov{\'a} and Milan Nobilis and Zbyněk Svoboda and Miroslav L{\'i}sa and Michal Hol{\vc}apek and Jaroslav Kvetina and Jiř{\'i} Klime{\vs} and Vladim{\'i}r Pali{\vc}ka},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2007},
  volume={853 1-2},
  pages={265-74}
}
Galantamine, an alkaloid isolated from the bulbs and flowers of Caucasian snowdrop (Galanthus woronowii, Amaryllidaceae) and related species, is employed in human medicine for the treatment of various neuromuscular and neurodegenerative diseases. After the administration, the products of oxidative biotransformation (O-desmethyl-galantamine, N-desmethyl-galantamine, galantamine-N-oxide) and chiral conversion (epigalantamine) are formed in various concentrations from parent compound. For the… CONTINUE READING