High-performance liquid chromatographic method for the determination of bromodeoxyuridine and its major metabolite, bromouracil, in biological fluids.

@article{Stetson1985HighperformanceLC,
  title={High-performance liquid chromatographic method for the determination of bromodeoxyuridine and its major metabolite, bromouracil, in biological fluids.},
  author={Philip L. Stetson and Umesh A. Shukla and Pinky Amin and William D. Ensminger},
  journal={Journal of chromatography},
  year={1985},
  volume={341 1},
  pages={217-22}
}
Administration of the halogenated nucleoside, 5-bromodeoxyuridine (BUDR) to mammalian systems is followed by its incorporation into DNA resulting in an increased susceptibility of mammalian cells to the lethal effects of x-irradiation [l-4] . Because tumor cells generally have higher turnover and therefore a higher DNA synthesis rate than the surrounding normal tissues, this radiosensitization effect of BUDR makes it a useful agent in the treatment of neoplastic disorders. Several clinical… CONTINUE READING