High-performance liquid chromatographic determination of a new pyrazoloquinoline type benzodiazepine receptor antagonist and its hydroxy metabolite.

Abstract

A rapid high-performance liquid chromatographic (HPLC) method for the determination of the novel benzodiazepine receptor antagonist 2-phenylpyrazolo[4,3-c]quinolin-3(5H)-one (CGS 8216) and its hydroxy metabolite is described. The method involves a solid-phase extraction with C18 disposable columns and quantification by HPLC with UV-detection. In plasma 20… (More)

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Cite this paper

@article{Jedrychowski1988HighperformanceLC, title={High-performance liquid chromatographic determination of a new pyrazoloquinoline type benzodiazepine receptor antagonist and its hydroxy metabolite.}, author={Maria Jedrychowski and Eckhart K. Schmidt and Peter R. Bieck}, journal={Arzneimittel-Forschung}, year={1988}, volume={38 4}, pages={495-7} }