High-performance liquid chromatographic assay of antiinflammatory drugs incorporated in gel ointments. Separation and stability testing.

  title={High-performance liquid chromatographic assay of antiinflammatory drugs incorporated in gel ointments. Separation and stability testing.},
  author={K. Yamamura and J. Yamada and T. Yotsuyanagi},
  journal={Journal of chromatography},
  volume={331 2},
High-performance liquid chromatographic determinations of gabexate mesilate (FOY), prostaglandin E1 (PGE1), PGE1-alpha-cyclodextrin (PGE1-CD), prednisolone (PD) and butyl flufenamate (BF) incorporated in gel ointment were investigated. The gel ointment is composed of a carboxy vinyl polymer (1.3%, w/w) and a large amount of an aqueous organic solvent. A methanol extraction system offered simultaneous advantages of the removal of the polymer and the recovery of active ingredients from the gel… Expand
Determination of ethyl-p-hydroxybenzoate in sow pancreatic juice by reversed-phase high-performance liquid chromatography.
The HPLC-DAD method proved to be sensitive, specific, accurate and precise and was successfully used to determine the ethyl-p-hydroxybenzoate (II) in sow pancreatic juice. Expand
Chromatographic Analysis of Pharmaceuticals
Regulatory Considerations for the Chromatographer, John A. Adamovics Sample Treatment, John A. Adamovics Planar Chromatography, John A. Adamovics and James C. Eschbach Gas Chromatography, John A.Expand
Enhanced Bioavailability of Subcutaneously Injected Insulin by Pretreatment with Ointment Containing Protease Inhibitors
Results indicate that gabexate or nafamostat ointments stabilize subcutaneous injected insulin. Expand


High-performance liquid chromatographic assay for prostaglandin E1 in various ointment vehicles. Separation and stability testing.
A high-performance liquid chromatographic method for the determination of prostaglandin E1 (PGE1) incorporated in white petrolatum, white ointment, hydrophilic petrolatum and Plastibase was investigated and the drug remained intact for up to 6 months when stored at 5 degrees C. Expand
Vehicle effects in percutaneous absorption: in vitro study of influence of solvent power and microscopic viscosity of vehicle on benzocaine release from suspension hydrogels.
The release through silicone rubber membranes of benzocaine suspended in carbomer hydrogels containing different concentrations of low molecular weight polysols was studied to establish general principles and procedures for control of the effects on percutaneous absorption caused by changes in drug solubility and/or diffusivity in the vehicle. Expand
Kinetics of decomposition and formulation of hydrocortisone butyrate in semiaqueous and gel systems.
The stability of hydrocortisone butyrate in semiaqueous and formulated gel systems has been investigated and the kinetics of decomposition is modeled using nonlinear regression analysis, and the rate constants for the various decomposition pathways are quantified. Expand