High-performance liquid chromatographic assay for methylprednisolone and its soluble prodrug esters in dog plasma.


A high-performance liquid chromatographic method with ultraviolet detection (lambda max = 243 nm) has been developed for the simultaneous determination of methylprednisolone (MP) and its water-soluble prodrug esters methylprednisolone hemisuccinate (MPS) and N,N,N'-triethylethylenediamine amide of 6 alpha-methylprednisolone-21-hemisuberate hydrochloride… (More)


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