High-performance liquid chromatographic analysis of doxacurium, a new long-acting neuromuscular blocker.

  title={High-performance liquid chromatographic analysis of doxacurium, a new long-acting neuromuscular blocker.},
  author={R. Deangelis and P. Loebs and R. Maehr and J. Savarese and R. Welch},
  journal={Journal of chromatography},
  volume={525 2},
A rapid and sensitive high-performance liquid chromatographic procedure was developed for the analysis of the new, long-acting neuromuscular blocker doxacurium in the plasma and urine of dog and man and in the bile of dog. Samples were prepared on solid-phase extraction cartridges containing a methyl (C1) bonded phase and were chromatographed on a 15 cm reversed-phase column (C1) using a mobile phase of 0.05 M monobasic potassium phosphate-acetonitrile (30:70, v/v). The compound was detected at… Expand
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Clinical Significance of Esterases in Man
  • F. Williams
  • Biology, Medicine
  • Clinical pharmacokinetics
  • 1985
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