High-performance liquid chromatographic analysis of doxacurium, a new long-acting neuromuscular blocker.

@article{Deangelis1990HighperformanceLC,
  title={High-performance liquid chromatographic analysis of doxacurium, a new long-acting neuromuscular blocker.},
  author={R. Deangelis and P. Loebs and R. Maehr and J. Savarese and R. Welch},
  journal={Journal of chromatography},
  year={1990},
  volume={525 2},
  pages={
          389-400
        }
}
A rapid and sensitive high-performance liquid chromatographic procedure was developed for the analysis of the new, long-acting neuromuscular blocker doxacurium in the plasma and urine of dog and man and in the bile of dog. Samples were prepared on solid-phase extraction cartridges containing a methyl (C1) bonded phase and were chromatographed on a 15 cm reversed-phase column (C1) using a mobile phase of 0.05 M monobasic potassium phosphate-acetonitrile (30:70, v/v). The compound was detected at… Expand
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References

SHOWING 1-7 OF 7 REFERENCES
Disposition of vecuronium bromide in the cat.
TLDR
There were no significant differences in pharmacokinetic data or in the amounts of vecuronium and its metabolites recovered in cats with ligated renal pedicles, and the 15% of veCuronium normally excreted by the kidney was compensated for by increased hepatic and biliary concentration of ve curonium. Expand
The Clinical Neuromuscular Pharmacology of Mivacurium Chloride (BW B1090U). A Short‐acting Nondepolarizing Ester Neuromuscular Blocking Drug
TLDR
Mivacurium may offer increased versatility in providing clinical muscle relaxation in a variety of situations, and further studies seem appropriate. Expand
Factors affecting the retention of quaternary ammonium ions in reversed-phase high-performance liquid chromatography.
TLDR
It was found that ternary eluents containing hexane sulphonic acid and two organic modifiers offer certain selectivity advantages when compared with binary eluENTs containing an ion-pairing agent. Expand
Cation exchange contribution to the retention of specific quaternary ammonium compounds in reversed-phase high-performance liquid chromatography.
TLDR
The retention data are consistent with the inclusion of an ion exchange contribution to the retention of cationic solutes in the systems investigated, and the counter anion of the added electrolyte did not perceptibly influence solute retention at constant mobile phase pH, although it did significantly influencesolute retention when the electrolytes were added to unbuffered mobile phases. Expand
Clinical Significance of Esterases in Man
  • F. Williams
  • Biology, Medicine
  • Clinical pharmacokinetics
  • 1985
TLDR
The concentration of aspirin relative to salicylate in the circulation may be affected by individual variation in esterase levels and the relative roles of the different esterases, and this may influence the overall pharmacological effect. Expand