High-performance calcium sensors for imaging activity in neuronal populations and microcompartments

@article{Dana2019HighperformanceCS,
  title={High-performance calcium sensors for imaging activity in neuronal populations and microcompartments},
  author={Hod Dana and Yi Sun and Boaz Mohar and Brad K. Hulse and Aaron M. Kerlin and Jeremy P. Hasseman and G. Bitsuamlak Tsegaye and Arthur Tsang and Allan M Wong and Ronak Patel and John J. Macklin and Yang Chen and Arthur Konnerth and Vivek Jayaraman and Loren L Looger and Eric R Schreiter and Karel Svoboda and Douglas S Kim},
  journal={Nature Methods},
  year={2019},
  volume={16},
  pages={649-657}
}
Calcium imaging with genetically encoded calcium indicators (GECIs) is routinely used to measure neural activity in intact nervous systems. GECIs are frequently used in one of two different modes: to track activity in large populations of neuronal cell bodies, or to follow dynamics in subcellular compartments such as axons, dendrites and individual synaptic compartments. Despite major advances, calcium imaging is still limited by the biophysical properties of existing GECIs, including affinity… CONTINUE READING
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