High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression.

@article{Westervelt2003HighpenetranceMM,
  title={High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression.},
  author={Peter Westervelt and Andrew A. Lane and Jessica L. Pollock and Kristie M Oldfather and Matthew S. Holt and Drazen B. Zimonjic and Nicholas C. Popescu and John F. DiPersio and Timothy J. Ley},
  journal={Blood},
  year={2003},
  volume={102 5},
  pages={1857-65}
}
Transgenic mice expressing PML-RARalpha in early myeloid cells under control of human cathepsin G regulatory sequences all develop a myeloproliferative syndrome, but only 15% to 20% develop acute promyelocytic leukemia (APL) after a latent period of 6 to 14 months. However, this transgene is expressed at very low levels in the bone marrow cells of transgenic mice. Because the transgene includes only 6 kb of regulatory sequences from the human cathepsin G locus, we hypothesized that sequences… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 57 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 33 references

PML-RAR kills U937 cells: a novel activity of PML-RAR that may contribute to APL pathogenesis [abstract

  • AA Lane, P Westervelt, TJ. Ley
  • Blood
  • 2002

Role of promyelocytic leukemia (PML) protein in tumor suppression

  • EM Rego, Wang Z-G, D Peruzzi, He L-Z, C CordonCardo, PP Pandolfi
  • J Exp Med
  • 2001

Similar Papers

Loading similar papers…