High oxygen prevents fetal lethality due to lack of catecholamines.

  title={High oxygen prevents fetal lethality due to lack of catecholamines.},
  author={Margie A Ream and Rashmi Chandra and Mary Peavey and Alisa M Ray and Suzanne K Roffler-Tarlov and Hyung-Gun Kim and William C. Wetsel and Howard A Rockman and Dona M. Chikaraishi},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={295 3},
The catecholamine norepinephrine is required for fetal survival, but its essential function is unknown. When catecholamine-deficient [tyrosine hydroxylase (Th) null] mouse fetuses die at embryonic day (E)13.5-14.5, they resemble wild-type (wt) fetuses exposed to hypoxia. They exhibit bradycardia (28% reduction in heart rate), thin ventricular myocardium (20% reduction in tissue), epicardial detachment, and death with vascular congestion, hemorrhage, and edema. At E12.5, before the appearance of… CONTINUE READING