High occupancy of sigma-1 receptors in the human brain after single oral administration of fluvoxamine: a positron emission tomography study using [11C]SA4503.

@article{Ishikawa2007HighOO,
  title={High occupancy of sigma-1 receptors in the human brain after single oral administration of fluvoxamine: a positron emission tomography study using [11C]SA4503.},
  author={Masatomo Ishikawa and Kiichi Ishiwata and Kenji Ishii and Yuichi Kimura and Muneyuki Sakata and Mika Naganawa and Keiichi Oda and Ryousuke Miyatake and Mihisa Fujisaki and Eiji Shimizu and Yukihiko Shirayama and Masaomi Iyo and Kenji Hashimoto},
  journal={Biological psychiatry},
  year={2007},
  volume={62 8},
  pages={878-83}
}
BACKGROUND Sigma-1 receptors might be implicated in the pathophysiology of psychiatric diseases, as well as in the mechanisms of action of some selective serotonin reuptake inhibitors (SSRIs). Among the several SSRIs, fluvoxamine has the highest affinity for sigma-1 receptors (Ki = 36 nM), whereas paroxetine shows low affinity (Ki = 1893 nM). The present study was undertaken to examine whether fluvoxamine binds to sigma-1 receptors in living human brain. METHODS A dynamic positron emission… CONTINUE READING

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