High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma.

@article{Carreras2006HighNO,
  title={High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma.},
  author={Joaquim Carreras and Armando L{\'o}pez-Guillermo and Bridget C Fox and Llu{\'i}s Colomo and Antonio Olivas Martinez and Giovanna Roncador and Emili Montserrat and El{\'i}as Campo and Alison H Banham},
  journal={Blood},
  year={2006},
  volume={108 9},
  pages={2957-64}
}
The tumor microenvironment plays an important role in the biologic behavior of follicular lymphoma (FL), but the specific cell subsets involved in this regulation are unknown. To determine the impact of FOXP3-positive regulatory T cells (Tregs) in the progression and outcome of FL patients, we examined samples from 97 patients at diagnosis and 37 at first relapse with an anti-FOXP3 monoclonal antibody. Tregs were quantified using computerized image analysis. The median overall survival (OS) of… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
185 Citations
41 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 185 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

Analysis of FOXP3-POSITIVE REGULATORY T CELLS IN FL 2963 BLOOD, 1 NOVEMBER

  • G Roncador, PJ Brown, L Maestre
  • For personal use only. on January
  • 2006

Molecular pathogenesis of follicular lymphoma: a cross talk of genetic and immunologic factors

  • D. de Jong
  • J Clin Oncol
  • 2005

Similar Papers

Loading similar papers…