High number of striatal dopaminergic neurons during early postnatal development: correlation analysis with dopaminergic fibers

Abstract

Dopamine (DA) axons in the developing striatum cluster in discrete areas called “DA islands”. During the third postnatal week, most DA islands are no-longer detectable and the DA innervation becomes uniform. In this study we explored the relationship between the pattern of DA innervation and the number of striatal tyrosine hydroxylase positive (TH+) cells during early postnatal development. By using dedicated stereology we found that the newborn striatum contains striatal TH+ cells, which cluster around newly sprouted DA axons. The number of these cells decreases when DA axons develop a full pattern of striatal innervation. This condition suggests a causal relationship between the amount of striatal DA innervation and the presence of striatal DA neurons. A better knowledge of the mechanisms regulating the ontogenesis of the nigrostriatal DA system may pave the way to strategies of neurorescue of the DA system.

DOI: 10.1007/s00702-008-0112-x

Extracted Key Phrases

5 Figures and Tables

Cite this paper

@article{Busceti2008HighNO, title={High number of striatal dopaminergic neurons during early postnatal development: correlation analysis with dopaminergic fibers}, author={Carla Letizia Busceti and Francesca Biagioni and Federica Mastroiacovo and Domenico Bucci and Paola Lenzi and Livia Pasquali and Angela Trabucco and Ferdinando Nicoletti and Francesco Fornai}, journal={Journal of Neural Transmission}, year={2008}, volume={115}, pages={1375-1383} }