High number of intraepithelial CD8+ tumor-infiltrating lymphocytes is associated with the absence of lymph node metastases in patients with large early-stage cervical cancer.

@article{Piersma2007HighNO,
  title={High number of intraepithelial CD8+ tumor-infiltrating lymphocytes is associated with the absence of lymph node metastases in patients with large early-stage cervical cancer.},
  author={Sytse J Piersma and Ekaterina S Jordanova and Mari{\"e}tte I E van Poelgeest and Kitty M. C. Kwappenberg and Jeanette M van der Hulst and Jan Wouter Drijfhout and Cornelis J M Melief and Gemma G Kenter and Gert Jan J Fleuren and Rienk Offringa and Sjoerd H van der Burg},
  journal={Cancer research},
  year={2007},
  volume={67 1},
  pages={354-61}
}
In a prospective study, we have examined the tumor-specific immune response in a group of 59 patients with human papillomavirus (HPV) 16-positive (HPV16(+))-induced or HPV18(+)-induced cervical cancer. Local antitumor immunity was analyzed by the enumeration of tumor-infiltrating dendritic cells and CD4+, CD8+, and regulatory T cells as well as by calculation of the ratio of CD8+/CD4+ T cells and CD8+/regulatory T cells. Systemic tumor-specific immunity was assessed by determination of the HPV… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 143 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2005
View 13 Excerpts
Highly Influenced

Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer.

Proceedings of the National Academy of Sciences of the United States of America • 2005
View 5 Excerpts
Highly Influenced

The status of HPV16-specific T-cell reactivity in health and disease as a guide to HPV vaccine development

SH van der Burg, A de Jong, MJ Welters, R Offringa, CJ. Melief
Virus Res 2002;89:275–84. Research. on April • 2007

Detection of human papillomavirus type 18 E6 and E7specific CD4+ T-helper 1 immunity in relation to health versus disease

MJ Welters, P van der Logt, SJ van den Eeden
Int J Cancer 2006;118:950–6 • 2006

Fourcolor staining combining fluorescence and brightfield microscopy for simultaneous immune cell phenotyping and localization in tumor tissue

RL van Vlierberghe, MH Sandel, FA Prins
sections. Microsc Res Tech 2005;67:15–21 • 2005
View 1 Excerpt

Similar Papers

Loading similar papers…