High nuclear expression of the apoptosis inhibitor protein survivin is associated with disease recurrence and poor prognosis in laryngeal basaloid squamous cell carcinoma.

@article{Marioni2006HighNE,
  title={High nuclear expression of the apoptosis inhibitor protein survivin is associated with disease recurrence and poor prognosis in laryngeal basaloid squamous cell carcinoma.},
  author={Gino Marioni and Giancarlo Ottaviano and Rosario Marchese-Ragona and Luciano Giacomelli and Andy Bertolin and Davide Zanon and F. Quinones Marino and Alberto Staffieri},
  journal={Acta oto-laryngologica},
  year={2006},
  volume={126 2},
  pages={
          197-203
        }
}
CONCLUSION Nuclear expression of survivin should be studied as a promising marker of higher-risk laryngeal basaloid squamous cell carcinomas (BSCCs), which can then be treated more aggressively and followed more closely. OBJECTIVE BSCC is an uncommon bimorphic variant of SCC. The hypothesized greater aggressiveness and poorer prognosis of head and neck BSCC compared to SCC are still under debate. The regulation of apoptotic cell death has a profound effect on the pathogenesis and progression… CONTINUE READING
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