High normal fasting glucose level in obese youth: a marker for insulin resistance and beta cell dysregulation

@article{OMalley2010HighNF,
  title={High normal fasting glucose level in obese youth: a marker for insulin resistance and beta cell dysregulation},
  author={Grace A. O’Malley and Nicola Santoro and Veronika Shabanova Northrup and Ebe D’Adamo and Melissa Shaw and Samuel Eldrich and Sonia Caprio},
  journal={Diabetologia},
  year={2010},
  volume={53},
  pages={1199-1209}
}
A high but normal fasting plasma glucose level in adults is a risk factor for future development of type 2 diabetes mellitus and cardiovascular disease. We investigated whether normal fasting plasma glucose levels (<5.60 mmol/l) are associated with decreases in insulin sensitivity and beta cell function, as well as an adverse cardiovascular profile in obese youth. We performed a cross-sectional analysis in a multiethnic sample of 1,020 obese youth (614 girls and 406 boys; mean age 12.9 years… CONTINUE READING

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a randomized controlled trial

M Savoye, M Shaw, Dziura J et al Effects of a weight management program on composition, metabolic parameters in overweight children
JAMA 297:2697–2704 Diabetologia • 2010
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