High neuroticism and depressive temperament are associated with dysfunctional regulation of the hypothalamic-pituitary-adrenocortical system in healthy volunteers.

@article{Zobel2004HighNA,
  title={High neuroticism and depressive temperament are associated with dysfunctional regulation of the hypothalamic-pituitary-adrenocortical system in healthy volunteers.},
  author={A. Zobel and Katrin Barkow and S. C. Schulze-Rauschenbach and Olrik C von Widdern and Martin Metten and Ute Pfeiffer and Susanne Schnell and Michael Wagner and Wolfgang Maier},
  journal={Acta psychiatrica Scandinavica},
  year={2004},
  volume={109 5},
  pages={392-9}
}
OBJECTIVE Elevated neuroticism, depressive temperament and dysfunctional regulation of the hypothalamic-pituitary-adrenocortical (HPA) system are considered as risk factors for unipolar depression. An interaction of these vulnerability factors was suggested, but controversially discussed. In absence of other informative studies we set out for a replication test and for elucidation of the underlying mechanism. METHOD Ninety-two subjects recruited in the community-performed assessments of… CONTINUE READING