High-multiplicity HIV-1 infection and neutralizing antibody evasion mediated by the macrophage-T cell virological synapse.

@article{Duncan2014HighmultiplicityHI,
  title={High-multiplicity HIV-1 infection and neutralizing antibody evasion mediated by the macrophage-T cell virological synapse.},
  author={Christopher J. A. Duncan and James Pate Williams and Torben Schiffner and Kathleen G{\"a}rtner and Christina Ochsenbauer and John C Kappes and R. Andy Russell and John A. Frater and Quentin J Sattentau},
  journal={Journal of virology},
  year={2014},
  volume={88 4},
  pages={
          2025-34
        }
}
Macrophage infection is considered to play an important role in HIV-1 pathogenesis and persistence. Using a primary cell-based coculture model, we show that monocyte-derived macrophages (MDM) efficiently transmit a high-multiplicity HIV-1 infection to autologous CD4(+) T cells through a viral envelope glycoprotein (Env) receptor- and actin-dependent virological synapse (VS), facilitated by interactions between ICAM-1 and LFA-1. Virological synapse (VS)-mediated transmission by MDM results in… CONTINUE READING
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