High mucosal serotonin availability in neonatal guinea pig ileum is associated with low serotonin transporter expression.

@article{Bian2007HighMS,
  title={High mucosal serotonin availability in neonatal guinea pig ileum is associated with low serotonin transporter expression.},
  author={Xiaochun Bian and Bhavik Patel and Xiaoling Dai and James J Galligan and Greg M Swain},
  journal={Gastroenterology},
  year={2007},
  volume={132 7},
  pages={
          2438-47
        }
}
BACKGROUND & AIMS 5-Hydroxytryptamine (5-HT) is a neurotransmitter and paracrine signaling molecule in the gut. Paracrine signaling by enterochromaffin cells (EC), which release 5-HT, has not been studied in neonates. Our aim was to compare 5-HT disposition in the intestinal mucosa of neonatal and adult guinea pigs. METHODS 5-HT was locally measured in vitro from intestinal segments using a diamond microelectrode and continuous amperometry. The serotonin transporter (SERT) was measured using… CONTINUE READING

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