High molecular weight polyglycerol-based multivalent mannose conjugates.

  title={High molecular weight polyglycerol-based multivalent mannose conjugates.},
  author={Jayachandran N Kizhakkedathu and A. Louise Creagh and Rajesh A. Shenoi and Nicholas A.A. Rossi and Donald Elliott Brooks and Timmy Chi Wing Chan and Jonathan Samuel Lam and Srinivasa R. Dandepally and Charles A. Haynes},
  volume={11 10},
We report the synthesis and characterization of multivalent mannose conjugates based on high molecular weight hyperbranched polyglycerols (HPG). A range of glycoconjugates were synthesized from high molecular weight HPGs (up to 493 kDa) and varying mannose units (22-303 per HPG). Hemagglutination assays using fresh human red blood cells and concanavalin A (Con A) showed that HPG-mannose conjugates exhibited a large enhancement in the relative potency of conjugates (as high as 40000) along with… CONTINUE READING