High-molecular-weight hyaluronan is a novel inhibitor of pulmonary vascular leakiness.


Endothelial cell (EC) barrier dysfunction results in increased vascular permeability, a perturbation observed in inflammatory states, tumor angiogenesis, atherosclerosis, and both sepsis and acute lung injury. Therefore, agents that enhance EC barrier integrity have important therapeutic implications. We observed that binding of high-molecular-weight… (More)
DOI: 10.1152/ajplung.00405.2009

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