High-molecular-weight hyaluronan – a possible new treatment for sepsis-induced lung injury: a preclinical study in mechanically ventilated rats

@article{Liu2008HighmolecularweightH,
  title={High-molecular-weight hyaluronan – a possible new treatment for sepsis-induced lung injury: a preclinical study in mechanically ventilated rats},
  author={Yunglong Liu and Cheng-Hung Lee and Rejmon Dedaj and Hang Zhao and Hicham Mrabat and A. Sheidlin and O. Syrkina and Pei-ming Huang and H. Garg and C. Hales and D. Quinn},
  journal={Critical Care},
  year={2008},
  volume={12},
  pages={R102 - R102}
}
IntroductionMechanical ventilation with even moderate-sized tidal volumes synergistically increases lung injury in sepsis and has been associated with proinflammatory low-molecular-weight hyaluronan production. High-molecular-weight hyaluronan (HMW HA), in contrast, has been found to be anti-inflammatory. We hypothesized that HMW HA would inhibit lung injury associated with sepsis and mechanical ventilation.MethodsSprague–Dawley rats were randomly divided into four groups: nonventilated control… Expand
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Therapeutic Effects of Hyaluronic Acid in Peritonitis-Induced Sepsis in Mice.
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