High molecular weight coffee melanoidins are inhibitors for matrix metalloproteases.

@article{Marco2011HighMW,
  title={High molecular weight coffee melanoidins are inhibitors for matrix metalloproteases.},
  author={Leticia Missagia De Marco and Sarah J Fischer and Thomas Henle},
  journal={Journal of agricultural and food chemistry},
  year={2011},
  volume={59 21},
  pages={11417-23}
}
High molecular (above 10 kDa) melanoidins isolated from coffee beans of varying roasting degree were found to be efficient inhibitors for the zinc-containing matrix metalloproteases MMP-1, MMP-2, and MMP-9 with IC(50) values ranging between 0.2 and 1.1 mg/mL in vitro. The inhibitory potential increased with roasting degree. No or only slight inhibition of… CONTINUE READING