High molecular weight FGF2: the biology of a nuclear growth factor

  title={High molecular weight FGF2: the biology of a nuclear growth factor},
  author={Katarina Chlebova and V{\'i}tezlav Bryja and Pavel Dvor{\'a}k and Alois Kozub{\'i}k and William R Wilcox and Pavel Krejc{\'i}},
  journal={Cellular and Molecular Life Sciences},
Fibroblast growth factor 2 (FGF2) is one of the most studied growth factors to date. Most attention has been dedicated to the smallest, 18kDa FGF2 variant that is released by cells and acts through activation of cell-surface FGF-receptor tyrosine kinases. There are, however, several higher molecular weight (HMW) variants of FGF2 that rarely leave their producing cells, are retained in the nucleus and act independently of FGF-receptors (FGFR). Despite significant evidence documenting the… CONTINUE READING

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