High-mobility group protein B1 (HMGB1) is a novel biomarker for human ovarian cancer.

  title={High-mobility group protein B1 (HMGB1) is a novel biomarker for human ovarian cancer.},
  author={Jie Chen and B. S. Xi and Yueran Zhao and Yonghao Yu and Jie Zhang and Chunyu Wang},
  journal={Gynecologic oncology},
  volume={126 1},
BACKGROUND High mobility group box l (HMGB1), a nuclear and extracellular protein, is implicated in some physiologic and pathologic conditions. In this study, we investigated the expression and function of HMGB1 in ovarian cancer. METHODS cDNA microarray analysis was performed to compare gene expression profiles of the highly invasive and the low invasive subclones derived from the SKOV3 human ovarian cancer cell line. Immunohistochemistry (IHC) staining was performed to investigate HMGB1… CONTINUE READING
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