High-mobility group boxes mediate cell proliferation and radiosensitivity via retinoblastoma-interaction-dependent and -independent mechanisms.

@article{Wang2012HighmobilityGB,
  title={High-mobility group boxes mediate cell proliferation and radiosensitivity via retinoblastoma-interaction-dependent and -independent mechanisms.},
  author={Li-li Wang and Qing-hui Meng and Yang Jiao and Jia-ying Xu and Chun-min Ge and Ju-ying Zhou and Eliot M. Rosen and Hai-chao Wang and Saijun Fan},
  journal={Cancer biotherapy & radiopharmaceuticals},
  year={2012},
  volume={27 5},
  pages={329-35}
}
Our previous studies have shown that high-mobility group box 1 (HMGB1) could physically associate with the retinoblastoma (RB) protein via an LXCXE (leucine-X-cysteine-X-glutamic; X=any amino acid) motif. An identical LXCXE motif is present in the HMGB1-3 protein sequences, whereas a near-consensus LXCXD (leucine-X-cysteine-X-asparagine; X=any amino acid) motif is found in the HMGB4 protein. In this study, we have demonstrated that like HMGB1, HMGB2-3 also associated with the RB in vitro and in… CONTINUE READING
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