High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts

@inproceedings{Whmaa2011HighMG,
  title={High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts},
  author={Heidi W{\"a}h{\"a}maa and Hanna Schierbeck and Hulda Sigridur Hreggvidsd{\'o}ttir and Karin Palmblad and Anne-Charlotte Aveberger and Ulf Andersson and Helena Erlandsson Harris},
  booktitle={Arthritis research & therapy},
  year={2011}
}
INTRODUCTION In addition to its direct proinflammatory activity, extracellular high mobility group box protein 1 (HMGB1) can strongly enhance the cytokine response evoked by other proinflammatory molecules, such as lipopolysaccharide (LPS), CpG-DNA and IL-1β, through the formation of complexes. Extracellular HMGB1 is abundant in arthritic joint tissue where it is suggested to promote inflammation as intra-articular injections of HMGB1 induce synovitis in mice and HMGB1 neutralizing therapy… CONTINUE READING

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