High mobility group box protein-1 (HMGB-1) as a new diagnostic marker in patients with acute appendicitis

@article{Albayrak2011HighMG,
  title={High mobility group box protein-1 (HMGB-1) as a new diagnostic marker in patients with acute appendicitis},
  author={Yavuz Albayrak and Ayşe Albayrak and Muhammet Çelik and Ibrahim Gelincik and Ismail Demiryılmaz and Rahşan Yıldırım and Bunyami Ozogul},
  journal={Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine},
  year={2011},
  volume={19},
  pages={27 - 27}
}
BackgroundThe aim of this prospective study was therefore to evaluate the diagnostic value of preoperative serum High Mobility Group Box Protein-1 (HMGB-1) levels in patients with Acute Appendicitis (AA) who show normal white blood cell count (WBC) counts.MethodOur study was carried out from October 2010 through November 2010 and included 20 healthy control group participants and 60 patients who presented at the emergency department of Erzurum Training and Research Hospital in Turkey with acute… Expand
Diagnostic Value of High-Mobility Group Box 1 (HMGB1) Protein in Acute and Perforated Appendicitis
TLDR
The serum levels of High-mobility group box 1 (HMGB1) protein in patients with acute and perforated appendicitis were higher than in patientsWith normal appendix, these findings could be useful to develop a new biomarker along with other laboratory tests for accurate diagnosis of patients with appendiciti. Expand
Evaluation of high mobility group box 1 protein as a presurgical diagnostic marker reflecting the severity of acute appendicitis
TLDR
Serum HMGB1 constitutes as a valuable marker in diagnosis of AA and positively correlated with hs-CRP level, mRNA and protein expression ofHMGB1 to a certain extent reflected the severity of AA. Expand
The role of high-mobility group box-1 (HMGB-1) in the management of suspected acute appendicitis: useful diagnostic biomarker or just another blind alley?
  • K. Søreide
  • Medicine
  • Scandinavian journal of trauma, resuscitation and emergency medicine
  • 2011
Acute abdominal pain is one of the most frequent reasons for admitting patients to the emergency department for surgical evaluation. A wide number of differential diagnoses are available and theirExpand
High Mobility Group box-1 (HMGB1) Protein As a Biomarker for Acute Cholecystitis.
TLDR
A potential role for HMGB1 as an effective biomarker in improving the diagnostic accuracy of acute cholecystitis when used in conjunction with the standard diagnostic tests is suggested. Expand
Comments on "Preliminary study of high mobility group box chromosomal protein 1(HMGB1) in ankylosing spondylitis patients ".
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This study test the serum HMGB1 levels in 71 AS patients and 40 healthy controls and the values were much higher than the previous report using the same ELISA kit, and it does not seem reliable to detectHMGB1 at a concentration over 1μg/ml. Expand
The Place of Calprotectin, Lactoferrin, and High-Mobility Group Box 1 Protein on Diagnosis of Acute Appendicitis with Children
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HMGB-1, calprotectin, and lactoferrin constitute novel markers in diagnosis of AA and their levels may be helpful for the clinicians to judge about the severity of the condition. Expand
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HMGB1 plays a key role in several pediatric diseases, opening new scenarios for diagnostic biomarkers and therapeutic strategies development, and discussing clinical and scientific implications in the field of pediatrics. Expand
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Supporting evidence is provided for HMGB1 as a potential biomarker either for the clinical diagnosis of high-risk AE cohorts or for evaluating ARDs, indicating that serum HMGB 1 is a sensitive and specific biomarker for discriminating asbestosis- and MM-affected individuals from healthy or AE individuals. Expand
High mobility group box chromosomal protein 1 in acute-on-chronic liver failure patients and mice with ConA-induced acute liver injury.
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The data from the present study suggest that HMGB1 plays a critical role in the systemic inflammation of ACLf and could be a potential therapeutic target in the treatment of ACLF. Expand
The performance of the alarmin HMGB1 in pediatric diseases: From lab to clinic
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The ubiquitously expressed nonhistone nuclear protein high‐mobility group box protein 1 (HMGB1) has different functions related to posttranslational modifications and cellular localization and initiates innate immunity through interacting with its reciprocal receptors. Expand
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