High-mobility group box family of proteins: ligand and sensor for innate immunity.

  title={High-mobility group box family of proteins: ligand and sensor for innate immunity.},
  author={Hideyuki Yanai and Tatsuma Ban and T. Taniguchi},
  journal={Trends in immunology},
  volume={33 12},
Recent discoveries in signal-transducing innate receptors have illustrated the close link between innate and adaptive immunity. These advances revisit a fundamental issue of immunology, the recognition of self and non-self molecules by the immune system. Indeed, mounting evidence has been provided that the sensing of self-derived molecules by the immune system is important for health and disease. The high-mobility group box (HMGB) proteins, particularly HMGB1, are self-derived immune activators… CONTINUE READING
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