High-mobility group box 1 protein may be a therapeutic target in inflammation.

In the review of this issue,1 the authors have illustrated and summarized thefindings andknowledge of how thehigh-mobility group box 1 protein (HMGB1)mediates in acute and chronic organ injuries. HMGB1 is a ubiquitously expressed nuclear factor. It is an important mediator of inflammation through receptors of the innate immune system. The inflammatory… CONTINUE READING