High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal

@article{Lotze2005HighmobilityGB,
  title={High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal},
  author={Michael T. Lotze and Kevin J. Tracey},
  journal={Nature Reviews Immunology},
  year={2005},
  volume={5},
  pages={331-342}
}
High-mobility group box 1 protein (HMGB1), which previously was thought to function only as a nuclear factor that enhances transcription, was recently discovered to be a crucial cytokine that mediates the response to infection, injury and inflammation. These observations have led to the emergence of a new field in immunology that is focused on understanding the mechanisms of HMGB1 release, its biological activities and its pathological effects in sepsis, arthritis, cancer and other diseases… Expand
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