High mobility group box 1 promotes small intestinal damage induced by nonsteroidal anti-inflammatory drugs through Toll-like receptor 4.

@article{Nadatani2012HighMG,
  title={High mobility group box 1 promotes small intestinal damage induced by nonsteroidal anti-inflammatory drugs through Toll-like receptor 4.},
  author={Yuji Nadatani and Toshio Watanabe and Tetsuya Tanigawa and Hirohisa Machida and Hirotoshi Okazaki and Hirokazu Yamagami and Kenji Watanabe and K Tominaga and Yasuhiro Fujiwara and Tetsuo Arakawa},
  journal={The American journal of pathology},
  year={2012},
  volume={181 1},
  pages={98-110}
}
Release of high mobility group box 1 (HMGB1) from damaged cells, which is involved in many types of tissue injuries, activates inflammatory pathways by stimulating multiple receptors, including Toll-like receptor 2 (TLR2), TLR4, and receptor for advanced glycation end-products (RAGE). Our objective was to determine the role of HMGB1 in nonsteroidal anti-inflammatory drug (NSAID)-induced damage of the small intestine. Oral indomethacin (10 mg/kg) induced damage to the small intestine and was… CONTINUE READING

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