High mobility group box 1 contributes to the pathogenesis of experimental pulmonary hypertension via activation of Toll-like receptor 4.

@article{Bauer2013HighMG,
  title={High mobility group box 1 contributes to the pathogenesis of experimental pulmonary hypertension via activation of Toll-like receptor 4.},
  author={Eileen M. Bauer and Richard Shapiro and Han Zheng and Ferhaan See Ahmad and David C Ishizawar and Suzy A. A. Comhair and Serpil C. Erzurum and Timothy R Billiar and Philip M. Bauer},
  journal={Molecular medicine},
  year={2013},
  volume={18},
  pages={
          1509-18
        }
}
Survival rates for patients with pulmonary hypertension (PH) remain low, and our understanding of the mechanisms involved are incomplete. Here we show in a mouse model of chronic hypoxia (CH)-induced PH that the nuclear protein and damage-associate molecular pattern molecule (DAMP) high mobility group box 1 (HMGB1) contributes to PH via a Toll-like receptor 4 (TLR4)-dependent mechanism. We demonstrate extranuclear HMGB1 in pulmonary vascular lesions and increased serum HMGB1 in patients with… CONTINUE READING
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