High-mobility group box-1 and its role in angiogenesis.

@article{Yang2014HighmobilityGB,
  title={High-mobility group box-1 and its role in angiogenesis.},
  author={Shuai Yang and Linxinyu Xu and Tianshu Yang and Fang Wang},
  journal={Journal of leukocyte biology},
  year={2014},
  volume={95 4},
  pages={
          563-74
        }
}
HMGB1 is an architectural chromatin-binding protein that can be released actively by activated cells or passively by dying cells and can serve as a DAMP molecule to drive the pathogenesis of inflammatory and angiogenic diseases. Through TLR4 and RAGE signaling pathways, HMGB1 could regulate vascular growth in vivo and in vitro through diverse mechanisms, including induction of proangiogenic cytokine release and activation of ECs, macrophages, EPCs, and mesoangioblasts, all of which could… CONTINUE READING
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