High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity.

@article{Bianchi2007HighmobilityGB,
  title={High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity.},
  author={Marco Emilio Bianchi and Angelo A. Manfredi},
  journal={Immunological reviews},
  year={2007},
  volume={220},
  pages={35-46}
}
Tissue damage occurs often in the life of mammals and is usually repaired. Dying cells are swiftly phagocytosed, but before disappearing, they alert surrounding cells to activate homeostatic programs. They release signals that recruit inflammatory cells to the site of injury, promote cell migration and cell division to replace dead cells, and activate the immune system in anticipation of microbial invasion. Many of these events involve high-mobility group box 1 protein (HMGB1), a nuclear… CONTINUE READING
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