High-mobility group box 1, oxidative stress, and disease.

  title={High-mobility group box 1, oxidative stress, and disease.},
  author={Daolin Tang and Rui Kang and Herbert J. Zeh and Michael T Lotze},
  journal={Antioxidants & redox signaling},
  volume={14 7},
Oxidative stress and associated reactive oxygen species can modify lipids, proteins, carbohydrates, and nucleic acids, and induce the mitochondrial permeability transition, providing a signal leading to the induction of autophagy, apoptosis, and necrosis. High-mobility group box 1 (HMGB1) protein, a chromatin-binding nuclear protein and damage-associated molecular pattern molecule, is integral to oxidative stress and downstream apoptosis or survival. Accumulation of HMGB1 at sites of oxidative… CONTINUE READING
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