High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis.

@article{Liu2013HighMP,
  title={High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis.},
  author={Julia C. Liu and Xiao Guan and Jeremy A Ryan and Ana G Rivera and Caroline S. Mock and Vishesh Agrawal and Anthony Letai and Paul H. Lerou and Galit Lahav},
  journal={Cell stem cell},
  year={2013},
  volume={13 4},
  pages={483-91}
}
Human embryonic stem cells (hESCs) are highly sensitive to DNA damage and have low survival ability relative to differentiated cells. We investigated the source of this difference by comparing damage response pathways in hESCs and differentiated cells. We found that hESCs undergo more rapid p53-dependent apoptosis after DNA damage than differentiated cells do. However, p53 localization and function are similar between hESCs and differentiated cells, suggesting that p53 alone cannot explain the… CONTINUE READING
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