High metabolic activity in the dorsal vagal complex of Brattleboro rats

  title={High metabolic activity in the dorsal vagal complex of Brattleboro rats},
  author={S. W. Shaver and M. Kadekaro and P. Gross},
  journal={Brain Research},
Receptor densities for angiotensin II and atriopeptin are particularly high in the dorsal vagal complex (DVC) of the caudal medulla oblongata. Measurements of glucose metabolism in individual components of the DVC, compared with those in Long-Evans rats, revealed that the area postrema was activated selectively both in water-sated and water-deprived Brattleboro rats, which have high circulating levels of angiotensin II. Other parts of the DVC, including subnuclei of the nucleus of the solitary… Expand
3 Citations
Efferent metabolic effects of area postrema stimulation in renal hypertensive rats
Disturbances of brainstem neurotransmission or tissue reactivity to postremal pathway activation thus appear to be part of the central pathophysiology of chronic renal hypertension. Expand
Atriopeptin prevents angiotensin II-stimulated glucose utilization in the subfornical organ
Findings indicate that atriopeptin III, an atrial natriuretic peptide, may act at the level of subfornical organ to antagonize the dipsogenic action of ANG II. Expand


Local cerebral glucose utilization in Long-Evans and Brattleboro rats during acute dehydration.
In Long-Evans rats, water deprivation increased metabolic activity in the subfornical organ, in several structures with which it is connected, and in other brain regions putatively involved in maintaining fluid balance. Expand
Organization of atriopeptin‐like immunoreactive neurons in the central nervous system of the rat
The most prominent collection of APir perikarya was found in the hypothalamus, adjacent to the anteroventral tip of the third ventricle, and APir neurons were observed in the pedunculopontine and laterodorsal tegmental nuclei, as well as in the ventral te segmental area. Expand
Organization of angiotensin II immunoreactive cells and fibers in the rat central nervous system. An immunohistochemical study.
The results of water deprivation and nephrectomy suggest that this staining does not represent uptake of circulating peptide, but instead, represents AII-containing neural connections, which is suggested that, at many different levels, AII serves as both a hormone and neurotransmitter for fluid balance. Expand
Elevated glucose utilization in the subfornical organ during dehydration
The results suggest that angiotensin II is an important stimulant of metabolism in the subfornical organ, and that converging stimuli have a synergistic effect on metabolic activity in this structure. Expand
Angiotensin II receptors in paraventricular nucleus, subfornical organ, and pituitary gland of hypophysectomized, adrenalectomized, and vasopressin-deficient rats.
  • E. Castrén, J. Saavedra
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1989
The results suggest that angiotensin II may have a corticoid-dependent role in the regulation of corticotropin-releasing hormone secretion, which could be important in the adaptation to elevated corticosterone secretion in stress. Expand
The central neural connections of the area postrema of the rat
These connections, when considered in the context of the known vagal afferent input and reduced blood‐brain barrier of AP, place this structure in a unique position to receive and modulate ascending interoceptive information and to influence autonomic outflow as well. Expand
Binding sites for atrial natriuretic factor (ANF) in brain: Alterations in Brattleboro rats
Findings are consistent with a selective upregulation of ANF-28 binding sites in the subfornical organ of Brattleboro rats which exhibit a profound disturbance in body fluid homeostasis. Expand
Organization of the projections of a circumventricular organ: The area postrema in the rat
Fluorescent retrograde double labeling studies confirmed the bilateral nature of the area postrema projection to the parabrachial nuclei, and it appears that individual areaPostrema neurons project to either side but not both sides of the dorsal pons. Expand
Autoradiographic localization of angiotensin II receptors in rat brain.
The studies have demonstrated that AII receptors are distributed in a highly characteristic anatomical pattern in the brain and are consistent with the emerging evidence for multiple roles of AII as a neuropeptide in the central nervous system. Expand
Plasma angiotensin II: dipsogenic levels and angiotensin-generating capacity of renin.
The results indicate that the endogenous RAS can readily produce the major effector peptide of the system so that circulating levels are well in excess of the dipsogenic threshold for AII. Expand